Preparation for Child Psych PRITE and Boards
Introduction
High-yield facts
- PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state
Black belt facts
- The absorption of Geodon is increased two-fold in the presence of food.
- At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels.
- common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150.
- Fat content of the food is not important.
- Increasing the PO dose does not compensate for lower absorption when on an empty stomach.
- i.e.doubling the pm dose when one has to skip dinner is not a working strategy
References
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011