Preparation for Child Psych PRITE and Boards
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** common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150. | ** common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150. | ||
** Fat content of the food is not important. | ** Fat content of the food is not important. | ||
| − | * Increasing the PO dose does not compensate for lower absorption when on an empty stomach **i.e.doubling the pm dose when one has to skip dinner is not a working strategy | + | * Increasing the PO dose does not compensate for lower absorption when on an empty stomach. |
| − | + | ** i.e.doubling the pm dose when one has to skip dinner is not a working strategy | |
| − | + | ||
===References=== | ===References=== | ||
Revision as of 19:15, 22 August 2011
Introduction
High-yield facts
- PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state
Black belt facts
- The absorption of Geodon is increased two-fold in the presence of food.
- At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels.
- common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150.
- Fat content of the food is not important.
- Increasing the PO dose does not compensate for lower absorption when on an empty stomach.
- i.e.doubling the pm dose when one has to skip dinner is not a working strategy
References
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011