Preparation for Child Psych PRITE and Boards
(→Black belt facts) |
|||
| Line 11: | Line 11: | ||
===Black belt facts=== | ===Black belt facts=== | ||
* The absorption of Geodon is increased two-fold in the presence of food. | * The absorption of Geodon is increased two-fold in the presence of food. | ||
| − | **At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels. | + | **At least '''500kcal''' is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels. |
| − | ** common advice to take | + | ** common advice to take Geodon with a snack is misleading: an apple is 100 Cal, granolar bar is about 150. |
| − | ** Fat content of the food is not important. | + | ** Fat content of the food ''is not important''. |
| − | * Increasing the PO dose does not compensate for lower absorption when on an empty stomach. | + | * Increasing the PO dose ''does not compensate'' for lower absorption when on an empty stomach. |
| − | ** i.e.doubling the | + | ** i.e.doubling the evening dose when one has to skip dinner is not a working strategy |
==References== | ==References== | ||
Revision as of 19:27, 22 August 2011
Introduction
Geodon in children
High-yield facts
- PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state
- Geodon is liver-metabolized by aldehyde oxidase; CYP 3A4 enzymes play a secondary role, and thus carabamezapine can decrease and ketoconazole can increase blood levels of Geodon.
- Just like other 2nd-gen antipsychotics, Geodon has a black-box warning for increased mortality in elderly with dementia.
Black belt facts
- The absorption of Geodon is increased two-fold in the presence of food.
- At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels.
- common advice to take Geodon with a snack is misleading: an apple is 100 Cal, granolar bar is about 150.
- Fat content of the food is not important.
- Increasing the PO dose does not compensate for lower absorption when on an empty stomach.
- i.e.doubling the evening dose when one has to skip dinner is not a working strategy
References
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011