Preparation for Child Psych PRITE and Boards
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| − | ===High-yield facts | + | ==Geodon in children== |
| − | *PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state | + | |
| + | ==High-yield facts== | ||
| + | * PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state | ||
| + | * Geodon is liver-metabolized by aldehyde oxidase; CYP 3A4 enzymes play a secondary role, and thus carabamezapine can decrease and ketoconazole can increase blood levels of Geodon. | ||
| + | * Just like other 2nd-gen antipsychotics, Geodon has a black-box warning for increased mortality in elderly with dementia. | ||
===Black belt facts=== | ===Black belt facts=== | ||
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** i.e.doubling the pm dose when one has to skip dinner is not a working strategy | ** i.e.doubling the pm dose when one has to skip dinner is not a working strategy | ||
| − | + | ==References== | |
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011 | Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011 | ||
Revision as of 19:24, 22 August 2011
Introduction
Geodon in children
High-yield facts
- PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state
- Geodon is liver-metabolized by aldehyde oxidase; CYP 3A4 enzymes play a secondary role, and thus carabamezapine can decrease and ketoconazole can increase blood levels of Geodon.
- Just like other 2nd-gen antipsychotics, Geodon has a black-box warning for increased mortality in elderly with dementia.
Black belt facts
- The absorption of Geodon is increased two-fold in the presence of food.
- At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels.
- common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150.
- Fat content of the food is not important.
- Increasing the PO dose does not compensate for lower absorption when on an empty stomach.
- i.e.doubling the pm dose when one has to skip dinner is not a working strategy
References
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011