Preparation for Child Psych PRITE and Boards
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| − | ===High-yield facts | + | ==Introduction== |
| − | *PO Geodon should be taken with food: GI absorption is increased two-fold to therapeutic | + | |
| + | |||
| + | ===High-yield facts=== | ||
| + | *PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state | ||
| + | |||
| + | ===Black belt facts=== | ||
| + | * The absorption of Geodon is increased two-fold in the presence of food. | ||
| + | **At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels. | ||
| + | ** common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150. | ||
| + | ** Fat content of the food is not important. | ||
| + | * Increasing the PO dose does not compensate for lower absorption when on an empty stomach **i.e.doubling the pm dose when one has to skip dinner is not a working strategy | ||
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===References=== | ===References=== | ||
Revision as of 19:14, 22 August 2011
Introduction
High-yield facts
- PO Geodon should be taken with food: GI absorption is significantly lower in the fasting state
Black belt facts
- The absorption of Geodon is increased two-fold in the presence of food.
- At least 500kcal is necessary to ensure therapeutic concentration at predictable (dose-dependent) levels.
- common advice to take it Geodon with a snack may be misleading: an apple is 100 Cal, granolar bar is about 150.
- Fat content of the food is not important.
- Increasing the PO dose does not compensate for lower absorption when on an empty stomach **i.e.doubling the pm dose when one has to skip dinner is not a working strategy
References
Thombre AG. Improved Ziprasidone Formulations with Enhanced Bioavailability in the Fasted State and a Reduced Food Effect. Pharm Res 2011