http://learnpsychiatry.org/w/index.php?title=Special:NewPages&feed=atom&hideredirs=1&limit=50&offset=&namespace=0&username=&tagfilter=Learn Psychiatry - New pages [en]2024-03-29T11:43:10ZPreparation for Child Psych PRITE and BoardsMediaWiki 1.25.2http://learnpsychiatry.org/w/index.php/AntipsychoticsAntipsychotics2022-08-26T15:55:07Z<p>Eugene Grudnikoff MD: Created page with "==Introduction== ==Dose Equivalence and Effect Size Meta-analysis== A useful meta-analysis was published in 2020 evaluating studies of acute symptoms of schizophrenia (1). *..."</p>
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<div>==Introduction==<br />
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==Dose Equivalence and Effect Size Meta-analysis==<br />
A useful meta-analysis was published in 2020 evaluating studies of acute symptoms of schizophrenia (1).<br />
* A number of antipsychotics demonstrated 95% response (ED95) (near maximum reduction in symptoms) well below their maximum licensed dose. For example, risperidone, which is licensed to be used at 16mg/day, showed ED95 at 6.26 mg/day and aripiprazole at 11.5 mg/day, while haloperidol's ED95 was only 6.3mg/day. <br />
*At their respective ED95 dose, risperidone had an effect size (SMD) of 0.6 and aripiprazole 0.42.<br />
* Conversely there was no clear plateau in response for clozapine at 600 mg (SMD >1) and olanzapine at 20mg (SMD 0.5), suggesting that higher doses may produce further response<br />
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[1] Stefan Leucht, M.D. et.al. '''Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia''' Am J Psychiatry 2020; 177:342–353</div>Eugene Grudnikoff MD