Preparation for Child Psych PRITE and Boards
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| − | * Non-responders to citalopram (Ci) (n= | + | * Non-responders to citalopram (Ci) (n=565) alone were randomized to '''Ci+Bupropion ER''' and '''Ci+Buspirone.''' Roughly 30% achieved remission in both groups. Bupropion ER group had fewer side effects and and greater reduction in symtpoms severity (NEJM 2006) |
Revision as of 15:52, 14 February 2013
Introduction
- Selective serotonin reuptake inhibitors (SSRIs) block the serotonin transporter on the pre-synaptic neuron, increasing the serotonin available to bind to the post-synaptic 5-HT receptors.
- SSRIs have very weak affinity for other mono-amine transporters (norepinephrine and dopamine reuptake).
SSRIs and Sleep
Major Studies
STAR*D
- Non-responders to citalopram (Ci) (n=565) alone were randomized to Ci+Bupropion ER and Ci+Buspirone. Roughly 30% achieved remission in both groups. Bupropion ER group had fewer side effects and and greater reduction in symtpoms severity (NEJM 2006)