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* significant clinical benefit of omega-3 treatment in depressive symtpoms in adults without MDD. | * significant clinical benefit of omega-3 treatment in depressive symtpoms in adults without MDD. | ||
* EPA (not DHA) is believed to be responsible for mental health benefits. | * EPA (not DHA) is believed to be responsible for mental health benefits. | ||
| − | * | + | * There was no benefit in '''prevention of depression''', or treatment of peripartum depression, schizophrenia, or dementia. |
| − | There was no benefit in '''prevention of depression''', or treatment of peripartum depression, schizophrenia, or dementia. | + | |
===Children and Adolescents=== | ===Children and Adolescents=== | ||
Revision as of 04:51, 30 August 2015
Contents
Introduction
Omega-3 polyunsaturated fatty acids (PUFA) include eicosapentaeoic acid (EPA) and docosahexaenoic acid (DHA). They are believed to be protective in cardiovascular disease due to their anti-infammatory properties.
This article summarizes current evidence for use of omega-3 fatty acids in psychiatry.
Omega-3 in mental health
Adults
Recent large meta-analysis of large number of placebo-controlled trials of PUFA for different indications revealed the following (1):
- significant clinical benefit of omega-3 treatment in major depressive disorder (MDD) and bipolar disorder
- significant clinical benefit of omega-3 treatment in depressive symtpoms in adults without MDD.
- EPA (not DHA) is believed to be responsible for mental health benefits.
- There was no benefit in prevention of depression, or treatment of peripartum depression, schizophrenia, or dementia.
Children and Adolescents
- A study of adolescents at risk for psychosis, omega-3 fatty acids significantly reduced positive symptoms, negative symptoms, and improved functioning, but had no significant effect on depressive symptoms. (2)
- A small RCT of depressed pre-teens found positive effect of omega-3 fatty acids in improving the mood.(3)
- Among children and adolescents with autism omega-3 fatty acids reduced severe tantrums, aggression, or self-injurious behavior at 6 weeks. (4)
References
1. Grosso G, et al. (2014) Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials. PLoS ONE 9(5): e96905.
2. Amminger GP, et al.(2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67:146–154.
3. Nemets H et.al. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006 Jun;163(6):1098-100. PMID:16741212
4. Amminger GP et.al. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.Biol Psychiatry. 2007 Feb 15;61(4):551-3. PMID:16920077
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