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4. Amminger GP et.al. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.Biol Psychiatry. 2007 Feb 15;61(4):551-3. PMID:16920077
 
4. Amminger GP et.al. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.Biol Psychiatry. 2007 Feb 15;61(4):551-3. PMID:16920077
 
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Revision as of 18:23, 16 September 2014

Introduction

Omega-3 polyunsaturated fatty acids (PUFA) include eicosapentaeoic acid (EPA) and docosahexaenoic acid (DHA). They are believed to be protective in cardiovascular disease due to their anti-infammatory properties.

Omega-3 in mental health

Aults

Recent large meta-analysis of large number of placebo-controlled trials of PUFA for different indications revealed the following (1):

  • significant clinical benefit of omega-3 treatment in major depressive disorder (MDD) and bipolar disorder
  • significant clinical benefit of omega-3 treatment in depressive symtpoms in adults without MDD.
  • EPA (not DHA) is responsible for clinical efficasy.

There was no benefit in prevention of depression, or treatment of peripartum depression, schizophrenia, or dementia.

Children and Adolescents

  • A study of adolescents at risk for psychosis, omega-3 fatty acids significantly reduced positive symptoms, negative symptoms, and improved functioning, but had no significant effect on depressive symptoms. (2)
  • A small RCT of depressed pre-teens found positive effect of omega-3 fatty acids in improving the mood.(3)
  • Among children and adolescents with autism omega-3 fatty acids reduced severe tantrums, aggression, or self-injurious behavior at 6 weeks. (4)

References

1. Grosso G, et al. (2014) Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials. PLoS ONE 9(5): e96905.

2. Amminger GP, et al.(2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67:146–154.

3. Nemets H et.al. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006 Jun;163(6):1098-100. PMID:16741212

4. Amminger GP et.al. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.Biol Psychiatry. 2007 Feb 15;61(4):551-3. PMID:16920077