Preparation for Child Psych PRITE and Boards
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==Absorption== | ==Absorption== | ||
'''Absorption''' is the process of getting the drug into the bloodstream. | '''Absorption''' is the process of getting the drug into the bloodstream. | ||
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'''Bioavailability''', a subcategory of absorption, is fraction of medication that reaches systemic ciculation. | '''Bioavailability''', a subcategory of absorption, is fraction of medication that reaches systemic ciculation. | ||
Absorption of PO medications takes place in the GI tract, maily in the small intestine, and thus affected by a number of factors: | Absorption of PO medications takes place in the GI tract, maily in the small intestine, and thus affected by a number of factors: | ||
| − | *GI tract conditions (acidity, chronic inflammation, acute diarrhea or emesis | + | *GI tract conditions (acidity, other food, chronic inflammation, gut flora, acute diarrhea or emesis) |
| − | + | *First-pass metabolism (may vary significantly from person to person) | |
| − | *First-pass metabolism | + | |
Bioavailablity of IV medications is by definition 100%. | Bioavailablity of IV medications is by definition 100%. | ||
Revision as of 18:42, 22 August 2011
Introduction
Although our website is oriented toward child and adolescent psychiatry, this review of drug metabolism will not be limited to pediatric topics. The subject matter is very important for all doctors and is extensively tested on PRITEs and Boards. Child-specific considerations will be addressed in a dedicated section below.
Absorption
Absorption is the process of getting the drug into the bloodstream.
Bioavailability, a subcategory of absorption, is fraction of medication that reaches systemic ciculation. Absorption of PO medications takes place in the GI tract, maily in the small intestine, and thus affected by a number of factors:
- GI tract conditions (acidity, other food, chronic inflammation, gut flora, acute diarrhea or emesis)
- First-pass metabolism (may vary significantly from person to person)
Bioavailablity of IV medications is by definition 100%.