Preparation for Child Psych PRITE and Boards
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* Depression during pregnancy is associated with increased risk of pre-term birth and low birth-weight ([http://www.ncbi.nlm.nih.gov/pubmed/20921117 Meta-analysis], Grote 2010) | * Depression during pregnancy is associated with increased risk of pre-term birth and low birth-weight ([http://www.ncbi.nlm.nih.gov/pubmed/20921117 Meta-analysis], Grote 2010) | ||
* Women treated with '''SSRI's''' have 2-3x greater risk for preterm birth and delivering low-birth-weight infants, compared to women not treated with SSRIs. | * Women treated with '''SSRI's''' have 2-3x greater risk for preterm birth and delivering low-birth-weight infants, compared to women not treated with SSRIs. | ||
| − | * Despite in-utero SSRI exposure, there was no effect in infant growth at 12-mo in a prospective observational [http://www.ncbi.nlm.nih.gov/pubmed/23511234 study] | + | * Despite in-utero SSRI exposure, there was no effect in infant growth at 12-mo in a prospective observational [http://www.ncbi.nlm.nih.gov/pubmed/23511234 study], i.e., premature and low-weight babies caught up. |
==Treatment== | ==Treatment== | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/20921117] Groto NK, et.al. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry. 2010 Oct;67(10):1012-24 | [http://www.ncbi.nlm.nih.gov/pubmed/20921117] Groto NK, et.al. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry. 2010 Oct;67(10):1012-24 | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/23511234] Wisner KL, et.al. Does Fetal Exposure to SSRIs or Maternal Depression Impact Infant Growth? Am J Psychiatry. 2013 May 1;170(5):485-93. | [http://www.ncbi.nlm.nih.gov/pubmed/23511234] Wisner KL, et.al. Does Fetal Exposure to SSRIs or Maternal Depression Impact Infant Growth? Am J Psychiatry. 2013 May 1;170(5):485-93. | ||
Revision as of 05:29, 5 May 2013
Introduction
General overview of depression can be found in the main article.
Epidemiology and Risk
- The incidence of MDD during pregnancy is 7.5%, while period prevalence is 12.7%.
- Depression during pregnancy is associated with increased risk of pre-term birth and low birth-weight (Meta-analysis, Grote 2010)
- Women treated with SSRI's have 2-3x greater risk for preterm birth and delivering low-birth-weight infants, compared to women not treated with SSRIs.
- Despite in-utero SSRI exposure, there was no effect in infant growth at 12-mo in a prospective observational study, i.e., premature and low-weight babies caught up.
Treatment
References
[1] Groto NK, et.al. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry. 2010 Oct;67(10):1012-24
[2] Wisner KL, et.al. Does Fetal Exposure to SSRIs or Maternal Depression Impact Infant Growth? Am J Psychiatry. 2013 May 1;170(5):485-93.