|
|
| Line 1: |
Line 1: |
| − | [[File:Placeholder|right|300px]]
| + | ==Introduction== |
| − | Write the text of your article here!
| + | This article discusses non-SSRI anti-depressants, such as tricyclic antidepressants, MAOI's, SNRI's, NDRI's, 5-HT-R antagonists and alpha-2 antagonists. |
| − | [[Category:Medications]]
| + | |
| | | | |
| − | Fluoxetine can cause early weight loss, but weight is usually recovered later in the course. (TT)
| + | '''Selective serotonin reuptake inhibitors''' are discussed [[SSRI|here]]. |
| | | | |
| − | ===Advanced topics===
| + | [[Category:Medications]] |
| − | SSRIs inhibit platelet aggregation, which can lead to bleeding in patients with von Willibrand desease, hemophilia, thrombocytopenia, or gastric ulcer.
| + | {{stub}} |
| − | *While SSRIs do not decrease platelet count, they inhibit platelet reuptake of 5-HT from serum, leading platelet 5-HT depletion.
| + | |
| − | **5-HT is an important pro-coagulant involved in primary hemostasis (platelet adhesion/aggregation/secretion of procagulants).
| + | |
| − | *SSRIs fluoxetine, sertraline, and paroxetine are most likely to increase bleeding time. Other antidepressants (venlafaxine, fluvoxamine, amitriptyline, imipramine and mirtazapine) impair hemostasis to a lesser degree. (Halperin 2007)
| + | |
| − | * Risk of GI bleed increases 12-fold with concominant use of SSRIs and NSAIDs (Dalton 2003)
| + | |
| − | | + | |
| − | ==References==
| + | |
| − | Halperin, Demian, Influence of antidepressants on hemolysis. Dialogues Clin. Neurosci. 2007 9:47-59. <br>
| + | |
| − | Dalton, SO. Use of serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding. Arch Inter Med. 2003; 163:59-64
| + | |
Latest revision as of 19:45, 21 August 2014
Introduction
This article discusses non-SSRI anti-depressants, such as tricyclic antidepressants, MAOI's, SNRI's, NDRI's, 5-HT-R antagonists and alpha-2 antagonists.
Selective serotonin reuptake inhibitors are discussed here.